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1.

Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.

Rivas, Martín A; Meydan, Cem; Chin, Christopher R; Challman, Matt F; Kim, Daleum; Bhinder, Bhavneet; Kloetgen, Andreas; Viny, Aaron D; Teater, Matt R; McNally, Dylan R; Doane, Ashley S; Béguelin, Wendy; Fernández, María Teresa Calvo; Shen, Hao; Wang, Xiang; Levine, Ross L; Chen, Zhengming; Tsirigos, Aristotelis; Elemento, Olivier; Mason, Christopher E; Melnick, Ari M.

Nat Immunol; 22(2): 240-253, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33432228

2.

Mapping genotypes to chromatin accessibility profiles in single cells.

Izzo, Franco; Myers, Robert M; Ganesan, Saravanan; Mekerishvili, Levan; Kottapalli, Sanjay; Prieto, Tamara; Eton, Elliot O; Botella, Theo; Dunbar, Andrew J; Bowman, Robert L; Sotelo, Jesus; Potenski, Catherine; Mimitou, Eleni P; Stahl, Maximilian; El Ghaity-Beckley, Sebastian; Arandela, JoAnn; Raviram, Ramya; Choi, Daniel C; Hoffman, Ronald; Chaligné, Ronan; Abdel-Wahab, Omar; Smibert, Peter; Ghobrial, Irene M; Scandura, Joseph M; Marcellino, Bridget; Levine, Ross L; Landau, Dan A.

Nature; 2024 May 08.

Artículo en Inglés | MEDLINE | ID: mdl-38720070

3.

MEN1 mutations mediate clinical resistance to menin inhibition.

Perner, Florian; Stein, Eytan M; Wenge, Daniela V; Singh, Sukrit; Kim, Jeonghyeon; Apazidis, Athina; Rahnamoun, Homa; Anand, Disha; Marinaccio, Christian; Hatton, Charlie; Wen, Yanhe; Stone, Richard M; Schaller, David; Mowla, Shoron; Xiao, Wenbin; Gamlen, Holly A; Stonestrom, Aaron J; Persaud, Sonali; Ener, Elizabeth; Cutler, Jevon A; Doench, John G; McGeehan, Gerard M; Volkamer, Andrea; Chodera, John D; Nowak, Radoslaw P; Fischer, Eric S; Levine, Ross L; Armstrong, Scott A; Cai, Sheng F.

Nature; 615(7954): 913-919, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36922589

4.

The BAFfling story of MN1-induced leukemogenesis.

Stonestrom, Aaron J; Levine, Ross L.

Mol Cell; 81(11): 2268-2269, 2021 06 03.

Artículo en Inglés | MEDLINE | ID: mdl-34087176

5.

Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.

Chen, Dong; Xia, Siyuan; Zhang, Rukang; Li, Yuancheng; Famulare, Christopher A; Fan, Hao; Wu, Rong; Wang, Mei; Zhu, Allen C; Elf, Shannon E; Su, Rui; Dong, Lei; Arellano, Martha; Blum, William G; Mao, Hui; Lonial, Sagar; Stock, Wendy; Odenike, Olatoyosi; Le Beau, Michelle; Boggon, Titus J; He, Chuan; Chen, Jianjun; Gao, Xue; Levine, Ross L; Chen, Jing.

Mol Cell; 81(18): 3833-3847.e11, 2021 09 16.

Artículo en Inglés | MEDLINE | ID: mdl-34289383

6.

Subtype-specific 3D genome alteration in acute myeloid leukaemia.

Xu, Jie; Song, Fan; Lyu, Huijue; Kobayashi, Mikoto; Zhang, Baozhen; Zhao, Ziyu; Hou, Ye; Wang, Xiaotao; Luan, Yu; Jia, Bei; Stasiak, Lena; Wong, Josiah Hiu-Yuen; Wang, Qixuan; Jin, Qi; Jin, Qiushi; Fu, Yihao; Yang, Hongbo; Hardison, Ross C; Dovat, Sinisa; Platanias, Leonidas C; Diao, Yarui; Yang, Yue; Yamada, Tomoko; Viny, Aaron D; Levine, Ross L; Claxton, David; Broach, James R; Zheng, Hong; Yue, Feng.

Nature; 611(7935): 387-398, 2022 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-36289338

7.

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis.

Fidler, Trevor P; Xue, Chenyi; Yalcinkaya, Mustafa; Hardaway, Brian; Abramowicz, Sandra; Xiao, Tong; Liu, Wenli; Thomas, David G; Hajebrahimi, Mohammad Ali; Pircher, Joachim; Silvestre-Roig, Carlos; Kotini, Andriana G; Luchsinger, Larry L; Wei, Ying; Westerterp, Marit; Snoeck, Hans-Willem; Papapetrou, Eirini P; Schulz, Christian; Massberg, Steffen; Soehnlein, Oliver; Ebert, Benjamin; Levine, Ross L; Reilly, Muredach P; Libby, Peter; Wang, Nan; Tall, Alan R.

Nature; 592(7853): 296-301, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33731931

8.

Single-cell mutation analysis of clonal evolution in myeloid malignancies.

Miles, Linde A; Bowman, Robert L; Merlinsky, Tiffany R; Csete, Isabelle S; Ooi, Aik T; Durruthy-Durruthy, Robert; Bowman, Michael; Famulare, Christopher; Patel, Minal A; Mendez, Pedro; Ainali, Chrysanthi; Demaree, Benjamin; Delley, Cyrille L; Abate, Adam R; Manivannan, Manimozhi; Sahu, Sombeet; Goldberg, Aaron D; Bolton, Kelly L; Zehir, Ahmet; Rampal, Raajit; Carroll, Martin P; Meyer, Sara E; Viny, Aaron D; Levine, Ross L.

Nature; 587(7834): 477-482, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-33116311

9.

Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.

Fortin, Jerome; Chiang, Ming-Feng; Meydan, Cem; Foox, Jonathan; Ramachandran, Parameswaran; Leca, Julie; Lemonnier, François; Li, Wanda Y; Gams, Miki S; Sakamoto, Takashi; Chu, Mandy; Tobin, Chantal; Laugesen, Eric; Robinson, Troy M; You-Ten, Annick; Butler, Daniel J; Berger, Thorsten; Minden, Mark D; Levine, Ross L; Guidos, Cynthia J; Melnick, Ari M; Mason, Christopher E; Mak, Tak W.

Proc Natl Acad Sci U S A; 120(4): e2208176120, 2023 01 24.

Artículo en Inglés | MEDLINE | ID: mdl-36652477

10.

DNA polymerase Î¸ protects leukemia cells from metabolically induced DNA damage.

Vekariya, Umeshkumar; Toma, Monika; Nieborowska-Skorska, Margaret; Le, Bac Viet; Caron, Marie-Christine; Kukuyan, Anna-Mariya; Sullivan-Reed, Katherine; Podszywalow-Bartnicka, Paulina; Chitrala, Kumaraswamy N; Atkins, Jessica; Drzewiecka, Malgorzata; Feng, Wanjuan; Chan, Joe; Chatla, Srinivas; Golovine, Konstantin; Jelinek, Jaroslav; Sliwinski, Tomasz; Ghosh, Jayashri; Matlawska-Wasowska, Ksenia; Chandramouly, Gurushankar; Nejati, Reza; Wasik, Mariusz; Sykes, Stephen M; Piwocka, Katarzyna; Hadzijusufovic, Emir; Valent, Peter; Pomerantz, Richard T; Morton, George; Childers, Wayne; Zhao, Huaqing; Paietta, Elisabeth M; Levine, Ross L; Tallman, Martin S; Fernandez, Hugo F; Litzow, Mark R; Gupta, Gaorav P; Masson, Jean-Yves; Skorski, Tomasz.

Blood; 141(19): 2372-2389, 2023 05 11.

Artículo en Inglés | MEDLINE | ID: mdl-36580665

11.

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and is a therapeutic target in myelofibrosis.

Dunbar, Andrew J; Kim, Dongjoo; Lu, Min; Farina, Mirko; Bowman, Robert L; Yang, Julie L; Park, Young; Karzai, Abdul; Xiao, Wenbin; Zaroogian, Zach; O'Connor, Kavi; Mowla, Shoron; Gobbo, Francesca; Verachi, Paola; Martelli, Fabrizio; Sarli, Giuseppe; Xia, Lijuan; Elmansy, Nada; Kleppe, Maria; Chen, Zhuo; Xiao, Yang; McGovern, Erin; Snyder, Jenna; Krishnan, Aishwarya; Hill, Corrine; Cordner, Keith; Zouak, Anouar; Salama, Mohamed E; Yohai, Jayden; Tucker, Eric; Chen, Jonathan; Zhou, Jing; McConnell, Timothy; Migliaccio, Anna R; Koche, Richard; Rampal, Raajit; Fan, Rong; Levine, Ross L; Hoffman, Ronald.

Blood; 141(20): 2508-2519, 2023 05 18.

Artículo en Inglés | MEDLINE | ID: mdl-36800567

12.

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.

Yoshimi, Akihide; Lin, Kuan-Ting; Wiseman, Daniel H; Rahman, Mohammad Alinoor; Pastore, Alessandro; Wang, Bo; Lee, Stanley Chun-Wei; Micol, Jean-Baptiste; Zhang, Xiao Jing; de Botton, Stephane; Penard-Lacronique, Virginie; Stein, Eytan M; Cho, Hana; Miles, Rachel E; Inoue, Daichi; Albrecht, Todd R; Somervaille, Tim C P; Batta, Kiran; Amaral, Fabio; Simeoni, Fabrizio; Wilks, Deepti P; Cargo, Catherine; Intlekofer, Andrew M; Levine, Ross L; Dvinge, Heidi; Bradley, Robert K; Wagner, Eric J; Krainer, Adrian R; Abdel-Wahab, Omar.

Nature; 574(7777): 273-277, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31578525

13.

The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm.

Zhang, Yong; Truong, Billy; Fahl, Shawn P; Martinez, Esteban; Cai, Kathy Q; Al-Saleem, Essel D; Gong, Yulan; Liebermann, Dan A; Soboloff, Jonathan; Dunbrack, Roland; Levine, Ross L; Fletcher, Steven; Kappes, Dietmar; Sykes, Stephen M; Shapiro, Paul; Wiest, David L.

Blood; 140(4): 359-373, 2022 07 28.

Artículo en Inglés | MEDLINE | ID: mdl-35436326

14.

Guiding the global evolution of cytogenetic testing for hematologic malignancies.

Akkari, Yassmine M N; Baughn, Linda B; Dubuc, Adrian M; Smith, Adam C; Mallo, Mar; Dal Cin, Paola; Diez Campelo, Maria; Gallego, Marta S; Granada Font, Isabel; Haase, Detlef T; Schlegelberger, Brigitte; Slavutsky, Irma; Mecucci, Cristina; Levine, Ross L; Hasserjian, Robert P; Solé, Francesc; Levy, Brynn; Xu, Xinjie.

Blood; 139(15): 2273-2284, 2022 04 14.

Artículo en Inglés | MEDLINE | ID: mdl-35167654

15.

BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation.

Li, Bing; An, Wenbin; Wang, Hua; Baslan, Timour; Mowla, Shoron; Krishnan, Aishwarya; Xiao, Wenbin; Koche, Richard P; Liu, Ying; Cai, Sheng F; Xiao, Zhijian; Derkach, Andriy; Iacobucci, Ilaria; Mullighan, Charles G; Helin, Kristian; Lowe, Scott W; Levine, Ross L; Rampal, Raajit K.

Blood; 139(25): 3630-3646, 2022 06 23.

Artículo en Inglés | MEDLINE | ID: mdl-35421216

16.

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.

Döhner, Hartmut; Wei, Andrew H; Appelbaum, Frederick R; Craddock, Charles; DiNardo, Courtney D; Dombret, Hervé; Ebert, Benjamin L; Fenaux, Pierre; Godley, Lucy A; Hasserjian, Robert P; Larson, Richard A; Levine, Ross L; Miyazaki, Yasushi; Niederwieser, Dietger; Ossenkoppele, Gert; Röllig, Christoph; Sierra, Jorge; Stein, Eytan M; Tallman, Martin S; Tien, Hwei-Fang; Wang, Jianxiang; Wierzbowska, Agnieszka; Löwenberg, Bob.

Blood; 140(12): 1345-1377, 2022 09 22.

Artículo en Inglés | MEDLINE | ID: mdl-35797463

17.

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation.

You, Xiaona; Liu, Fabao; Binder, Moritz; Vedder, Alexis; Lasho, Terra; Wen, Zhi; Gao, Xin; Flietner, Evan; Rajagopalan, Adhithi; Zhou, Yun; Finke, Christy; Mangaonkar, Abhishek; Liao, Ruiqi; Kong, Guangyao; Ranheim, Erik A; Droin, Nathalie; Hunter, Anthony M; Nikolaev, Sergey; Balasis, Maria; Abdel-Wahab, Omar; Levine, Ross L; Will, Britta; Nadiminti, Kalyan Vara Ganesh; Yang, David; Geissler, Klaus; Solary, Eric; Xu, Wei; Padron, Eric; Patnaik, Mrinal M; Zhang, Jing.

Blood; 139(7): 1066-1079, 2022 02 17.

Artículo en Inglés | MEDLINE | ID: mdl-34699595

18.

15 years after a giant leap for cancer genomics.

Cai, Sheng F; Levine, Ross L.

Nature; 623(7989): 920-921, 2023 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-38012374

19.

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.

Intlekofer, Andrew M; Shih, Alan H; Wang, Bo; Nazir, Abbas; Rustenburg, Ariën S; Albanese, Steven K; Patel, Minal; Famulare, Christopher; Correa, Fabian M; Takemoto, Naofumi; Durani, Vidushi; Liu, Hui; Taylor, Justin; Farnoud, Noushin; Papaemmanuil, Elli; Cross, Justin R; Tallman, Martin S; Arcila, Maria E; Roshal, Mikhail; Petsko, Gregory A; Wu, Bin; Choe, Sung; Konteatis, Zenon D; Biller, Scott A; Chodera, John D; Thompson, Craig B; Levine, Ross L; Stein, Eytan M.

Nature; 559(7712): 125-129, 2018 07.

Artículo en Inglés | MEDLINE | ID: mdl-29950729

20.

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.

Han, Dali; Lu, Xingyu; Shih, Alan H; Nie, Ji; You, Qiancheng; Xu, Meng Michelle; Melnick, Ari M; Levine, Ross L; He, Chuan.

Mol Cell; 63(4): 711-719, 2016 08 18.

Artículo en Inglés | MEDLINE | ID: mdl-27477909

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